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The reasons for the opposite results are mainly due to the different animal models, different observation time windows and different observation sites in each study
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When caloric restriction is present, mammals synthesise less IGF-1 and its synthesis in the liver is refractory to GH stimulation [128130]
Low levels of ROS act as important cellular signaling molecules involved in multiple life activities such as gene expression, cell proliferation, differentiation, and stress responses
[DOI] [PubMed] [Google Scholar] 125.Da Silveira Cruz-Machado S., Pinato L., Tamura E.K., Carvalho-Sousa C.E., Markus R.P
