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[DOI] [PubMed] [Google Scholar] 52.Zakzanis K.K., Campbell Z., Jovanovski D

Figure 3 Direct activation of mast cells Many small molecule drugs directly activate mast cells in an IgE-independent manner, which can immediately provoke the degranulation of mast cells and initiate the rapid release of multiple inflammatory mediators, such as histamine, tryptase, serotonin, heparin, and proteases

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Willers C

However, randomized trials on its potential use for cancer prevention have mostly yielded negative results (117, 123)