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Other key signaling pathways that are utilized are the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathways, as well as SH2B1, a scaffold protein that interacts with JAK2 and mediates GH-induced changes in the cytoskeleton

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tb by maintaining CD4 + and CD8 + T cell viability and function within infected granulomas stimulating an increase in the production of the immuno-supportive cytokines IFN- and TNF- and increasing autophagy ( M