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FIGURE 8 The lung histopathologic analysis at 4 weeks post-infection revealed multiple and poorly demarcated granulomatous lesions in all M

As early as a few decades ago, it was shown that the glycocalyx covers the surface of most vascular lumens and that microcirculatory dysfunction and endothelial damage play important roles in the multiorgan failure associated with sepsis (53), and also that endothelial dysfunction and microcirculatory impairment are determinants of the severity and duration of sepsis (54)