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Studies have shown that TGF-1 suppresses GCL expression via the JNKATF3 pathway, leading to GSH depletion and enhanced oxidative stress through increased protein and lipid peroxidation [121]

Modulation of Transforming Growth Factor-Beta (TGF-Beta) Signaling by Endogenous Sphingolipid Mediators

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A recent analysis showed decreased NADH levels within the retinas of patients with MS 223 and an altered NAD + /NADH ratio in the serum of patients with MS, indicating chronic oxidative stress 224

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