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Among different classes of copper ionophores, ES has exhibited acceptable safety and therapeutic efficiency in the clinical practice

Common analytical methods include HPLC, mass spectrometry, molecular weight analysis, and analytical assay verification

Additionally, oral contraceptives, FSH, LH, and gonadotropin-releasing hormone (GnRH) analogs, metformin, letrozole, and laparoscopic ovarian drilling (LOD) are also used to treat PCOS

In both regions, NSPCs are immersed in a particular microenvironment composed of diverse cellular constituents, such as astrocytes, pericytes, ependymocytes, and vascular and microglial cells (Batiz et al., 2015

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