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The datasets were all generated from the ROSMAP cohort, these included the single cell transcriptomic data from the prefrontal cortex region (snRNAseqPFC_BA10) (Syn18485175) 52 ( bulk RNA-seq data of dorsolateral prefrontal cortex (DLPFC), posterior cingulate gyrus (PCG), and anterior cingulate (AC) regions (syn3388564) 134 ( and the non-targeted metabolomics data form DLPFC region (syn3157322) ( Key clinical and pathological features of de-identified subjects included in these studies can be found in Supplementary Data 1

In order to further characterize this effect, -Glu-Glu was then tested on cells expressing either of GluN1 and GluN2A or GluN1 and GluN2B NMDAr subunits, bearing in mind that they are the most abundant NMDA receptors found in the hippocampus ( NMDA receptors were expressed first in astroglioma C6 cells

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& Jetten, M

Takai, D