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Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase

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Thyroid-associated ophthalmopathy and ferroptosis: a review of pathological mechanisms and therapeutic strategies

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Yang et al., 2014), which finally caused an imbalance of homeostatic oxygen homeostasis, leading to ferroptosis ( via CRISPR-Cas9 proved that the cystine/glutamate exchanger xCT is essential for amino acid and redox homeostasis in the ferroptosis process (Jiang et al., 2015