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The higher efficacy of these NP formulations compared to conventional forms across numerous criteria, including liver function markers, inflammatory cytokines, oxidative stress indicators, and histological features, highlights their promise as a novel therapeutic method for ALF

Mechanistically, T3 induces THRSP, which enhances LKB1/AMPK/Raptor (regulatory-associated protein of TOR) signaling while inhibiting the excessive activation of the PI3K/Akt/mTOR pathway

By combining the pathological characteristics of RF (e.g., changes in ECM composition and receptor expression), we should utilize intelligent nano-systems, integrate microenvironment-responsive drug release and multi-target intervention, enhance carrier biocompatibility and targeting precision, avoid potential renal injury, and accelerate their clinical translation (Fig

10.1177/106002808301701101 143 HanH

Macrophage proresolving mediators-the when and where