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Suicidal Thinking and Behavior Counsel patients, their caregivers, and families that AEDs, including Depakote Sprinkle Capsules, may increase the risk of suicidal thoughts and behavior and to be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm

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Not surprisingly, for a constellation of symptoms and disorders as broad as those described under the umbrella term LC, no single therapeutic intervention with a proven benefit for all affected patients exists
