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For successful NADs design, critical factors must be considered regarding sequence design, modification, and delivery, as well as the clinical translation, medical indication, and scale production feasibility

Gut microbiota dysbiosis in PD patients may increase intestinal permeability, exposing the enteric plexus to various toxins

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Pinhasov A, Mandel S, Torchinsky A, Giladi E, Pittel Z, Goldsweig AM, et al

Astrocytes promote the growth of neurites by releasing neurotrophic factors and reducing neurotoxicity by Glu uptake after brain injuries [76], while also protecting neurons from oxidative stress via a GSH-dependent mechanism [74,75]