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As a replacement strategy, lithium orotate (LiO), reported to bind A less avidly than lithium carbonate, raised parenchymal Li, reduced A and phospho-tau, and improved synaptic/myelin markers and behavior at physiological Li levels in AD mice, though these salt-specific advantages and translational implications remain preclinical [2123]

[116] conducted research to see if delivering insulin into the brain of people with Alzheimers disease or amnestic moderate cognitive impairment (MCI) would improve memory without increasing plasma insulin levels

S2CID 27736207

doi: 10.1177/1753425917704299 124 ZhuYLiHDingSWangY

Dynamics of Structural Elements of GB1 -Hairpin Revealed by TryptophanCysteine Contact Formation Experiments