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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

10.1016/j.neuropharm.2007.10.011 235 SidhpuraN.WeissF.Martin-FardonR
doi: 10.1248/bpb.30.1748

If it was there would be signs of tolerance by the time but the neurogenic effect takes place over time
