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Dopamine-releasing axons in the nigrostriatal pathway synapse onto GABAergic medium spiny neurons in the striatum

doi: 10.3389/fmicb.2025.1733315 Received 27 October 2025 Revised 04 December 2025 Accepted 05 December 2025 Published 16 December 2025 Volume 16 - 2025 Edited by Xiaoyuan Wei, University of South Florida, United States Reviewed by Chung-Yao Yang, Hygeia Touch Inc., Taiwan Milena Camargo, Centro de Tecnologa en Salud (CETESA)-Innovaseq SAS, Colombia Jhommara Bautista, University of the Americas, Ecuador Updates Copyright 2025 Feng, Song, Ren, Xu, Li, Feng and Wang

If despite best efforts to guide a patient, there is yet an unwillingness or inability to adhere to tapering guidelines, preparing a voluntary safety contract, sometimes called a Ulysses Contract will help keep things on track should the person become resistive to following the doctors orders

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The underlying mechanisms are multifaceted, encompassing metabolic reprogramming, nutritional support, direct anti-fibrotic actions, detoxification, and immunomodulation [176,177]