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Results and discussion Primary fragment screening by X-ray crystallography Due to its broad affinity detection range (nanomolar to millimolar) and unique ability to initiate rational drug design 30 , we carried out a crystallographic fragment screen against TRF1 TRFH at the XChem facility of the Diamond Light Source 30

Further studies on the alkylation of nucleic acids and their constituent nucleotides

Cytoplasmic NADPH Generating Pathways Pentose Phosphate Pathway Enzymes Several important biochemical pathways, that generate NADPH, are not directly related to NAD + synthesis and salvage

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