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Mice deficient in fatty acid -oxidation enzymes, including very-long-chain acyl-CoA dehydrogenase (VLCAD), long-chain acyl CoA dehydrogenase (LCAD), and short-chain acyl CoA dehydrogenase (SCAD) also displayed cold intolerance 40,41,42

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An inherited form of hyperhomocysteinemia results from mutations in the methylene tetrahydrofolate reductase (MTHFR) gene