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2021 Sep 6;13(9)

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice

observed decreased mitochondrial DNA (mtDNA) content accompanied by reductions in mtDNA-encoded proteins

More recent systematic reviews and meta-analyses published between 2020 and 2022 have broadly confirmed this picture, reporting small, short-term reductions in body weight and body mass index, particularly in older adults and individuals with obesity or metabolic conditions, but with effect sizes that remain clinically modest

Clinical Anatomy 2006
