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Inhibition of system Xc- expression leads to decreased GSH production, thus affecting GPX4 activity and inducing ferroptosis [40, 41]

Absolutely, but with a few important caveats

The bloodbrain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2

The future outlook focuses on rational combination therapies, such as pairing immune checkpoint inhibitors with specific drugs that break this cycle, as indicated by numerous combinations strategies 199

[DOI] [PubMed] [Google Scholar] 101.Hamzeh N., Li L., Barkes B., Huang J., Canono B., Gillespie M., Maier L., Day B
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