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Studies have shown that glutamate exposure or hypoxia/ischemia can trigger the activation of extrasynaptic NMDARs, activate the shutdown of cAMP response element-binding protein (CREB), and lead to mitochondrial membrane-potential loss and cell death (Figure 1)

We are not ever creating new water so that is what makes it so important that we take care of the water we have

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Acta Pharmacol Sin 45 , 150165 (2024)