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In the context of the autonomic nervous system, demyelination can disrupt the signals that control heart rate and blood pressure, contributing directly to the symptoms of dysautonomia

Because folate helps break down homocysteine, low folate can lead to high homocysteine levels, also known as hyperhomocysteinemia

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In PCOS patients, hyperphosphorylation of serine residues ( e.g ., Ser307, Ser636) on IRS-1/2 suppresses their tyrosine phosphorylation, thereby impairing the downstream PI3K/AKT signaling pathway