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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Mitchell J.R., Jollow D.J., Potter W.Z., Gillette J.R., Brodie B.B

In order to bind both targets and still maintain the overall structure of a typical antibody, four unique heavy and light chains were paired by engineering amino acid substitutions known as charge pairs ( To assess the safety and tolerability of AMG 966, a double-blind, placebo-controlled, first-in-human study was initiated in healthy subjects

Gillet JP, Calcagno AM, Varma S, Marino M, Green LJ, Vora MI, et al

Amino acids combine in different patterns to make all of the proteins in the body

SERT, serotonin transporter