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The improper regulation of autophagy during hypoxia has been linked to tumor growth, spread, and resistance to both chemotherapy and radiation
.,MaX,MaJ,LengT,YuanZ,HuT,LiuQShenTAdvances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention.2023;451:2146512 92
doi: 10.1016/j.fsi.2017.11.043
Journal of ethnopharmacology, 160 , 219226
This results in mitochondrial dysfunction, characterised by diminished Ca2+ flux, reduced mitochondrial ROS production, and intracellular acidosis, all contributing to the impairment of forward motility and fertility
