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Many solid tumors show little to no response to ICIs or develop acquired resistance, largely due to the immunosuppressive state of the tumor microenvironment, often referred to as cold tumors [356]

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Challenges in Stability, Delivery, and Toxicity Although AMPs hold great promise for the treatment of bacterial infections, the clinical use is encumbered by several major challenges, the most significant of which pertain to their susceptibility to host and bacterial proteolytic enzymes, thereby affecting their stability and diminishing their therapeutic half-life [177]