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Extreme variability of phenotype in patients with an identical missense mutation in the lamin A/C gene: From congenital onset with severe phenotype to milder classic EmeryDreifuss variant

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Bavbek N., Akay H., Uz B., Uz E., Turgut F., Kanbay M., Senes M., Akcay A., Duranay M

Neuroprotective action of valproic acid accompanied of the modification on the expression of Bcl-2 and activated caspase-3 in the brain of rats submitted to ischemia/reperfusion

The activation of mTORC1 by leucine occurs through sensing mechanisms including Sestrin2 and leucyl-tRNA synthetase, which facilitate the phosphorylation of downstream effectors such as p70 S6 kinase 1 and 4E-BP1, thereby initiating translation and augmenting myofibrillar protein synthesis

Aug 2020;24(15):7946-7952