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Eligible patients were required to be 18 years of age or older with NF1 and symptomatic, inoperable PN

Lin YF, Hassan Z, Talukdar S, Schat H, Aarts MG (2016) Expression of the ZNT1 zinc transporter from the metal hyperaccumulator Noccaea caerulescens confers enhanced zinc and cadmium tolerance and accumulation to Arabidopsis thaliana

Another risk factor is old age, where the stomach acid, required to absorb the vitamin, reduces with age

The diminished removal of cellular components encourages post-translational modification and consequent generation of novel epitopes that stimulate inflammation

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