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The pathogenesis of RA is complex, and dysfunction of Tregs is one of the potential mechanisms leading to the progression of RA

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R is the gas constant (8.314 J.K -1 mol -1 ), T (310.15 K 25 C), n is the number of transferred electrons (2) and F is Faradays constant (96485 C mol -1 )

Brain oxidative stress was determined as the GSSG/GSH ratio in hippocampus as previously described (Ezquer et al., Determination of Astrocyte and Microglia Immunoreactivity Following continuous chronic ethanol intake for 48 days, animals were alcohol deprived for 14 days and treated for the last 4 days of deprivation with either LY341495/NAC, SZ/NAC, LY341495/vehicle, SZ/vehicle, or vehicle/vehicle and then offered ethanol access for two consecutive days