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In response to the dopaminergic neural activation induced by substances of abuse, such as heroin (119, 120), methamphetamine (121, 122), and cocaine (123), the mitochondrial respiratory chain is rapidly activated, leading to mitochondrial dysfunction, such as decreased mitochondrial membrane potential, mitochondrial DNA, and mitochondrial proteins, and increased cytochrome c release, resulting in increased ROS and oxidative stress (124)

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Therefore, maintaining adequate levels of glutathione is vital for supporting a robust immune system and preventing diseases linked to oxidative stress

132 Several phytocompounds, such as Sapidolide A, 47 allicin, 133 and berberine, 134 have been shown to inhibit inflammasome activation and alleviate APAP-induced hepatotoxicity

Inconsistent application Sporadic copper peptide use produces sporadic results