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As iron accumulation favors ROS generation and ferroptosis, it is plausible that the high iron exposure in the intestine is related to the tissues increased sensitivity to IR

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This is indicated by increased serum creatinine and an increased risk for diabetes in G6PD-deficient subjects (28, 74, 90, 108, 109) and albuminuria and metabolic dysfunction in deficient animals (40, 111, 115), which could have adverse cardiac effects