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Catalysis by GSToccurs through the combined capacity of the enzyme to promote GS - formation and to bind hydrophobic electrophilic compounds at a closely adjacent site [3]

Histologically, more than 90% of tumours are epithelial, of which high-grade serous carcinoma (HGSC) dominates and alone explains about 70% of deaths [42]

Mapping Microenvironment-Mediated Signaling Dependency of Targeted Inhibitors: A Mechanism-Based Approach of Selecting Effective Therapy Targeting Drug Resistant AML

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At varying time points (0, 2, 5, 15, 30 min), purified Pt GSTF8 (8 M) and GSH (20 M) were added to an aliquot of the equilibration reaction and the resulting mixtures were incubated at 30 C for 30 min at 1200 rpm using a 3 mm shaking diameter before extraction with 2 vol of 75% methanol in H 2 O, 1 mM EDTA, 0.3% hydrochloric acid