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P1851, Sigma) 2-mercaptoethanol (Cat
Sha W, Zhao B, Wei H, Yang Y, Yin H, Gao J, et al
Continuous administration without washout can lead to adaptive downregulationwhere receptors become less responsive to MOTS-c signaling or NNMT inhibition becomes less effective due to compensatory upregulation
ECM hardening can lead to intracellular contraction, which in turn increases the hardness of the actin cytoskeleton, which is conducive to tumor migration (81) (81)
Larger clinical trials evaluating the combination remain limited
