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5-Amino-1MQ functions as a competitive inhibitor at the nicotinamide substrate site of NNMT, with an IC50 of 1.2 M against human NNMT
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This retention advantage may explain why some patients feel more prolonged effects from methylcobalamin even if blood levels look similar
Cell Metab 33 , 10761087
These findings have stimulated clinical development attempts, particularly for NAD + modulators deemed suitable for human trials in terms of safety and upscaling, such as natural precursors
