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HK2 interacts with nuclear proteins such as Max, Sirt1, IWS1, CTR9, and Spin1, increasing chromatin accessibility to regulate gene expression

Zecheng L, Donghai L, Runchuan G, Yuan Q, Qi J, Yijia Z, Shuaman R, Xiaoqi L, Yi W, Ni M, Yijin Q, Liang P, Jun W

one function of GSH is to detoxify oxidants by donating an electron

Whereas we focused on analysing acute response to PDF, Mezan et al

on the other hand, the reduced form of CoQ 10 (CoQ 10 -H 2 ) is a potent lipophilic antioxidant, which can capture LOO to prevent the spread of free radical chain reaction and inhibit the production of LOOHs, and meanwhile the CoQ 10 -H 2 is oxidized ( 10 synthesis will disrupt GPX4 synthesis and CoQ 10 -H 2 antioxidant activity respectively, and eventually induce ferroptosis