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Synopsis This study investigates the impact of excessive glutathione intake on breast cancer chemotherapy resistance, showing that higher intake is linked to increased recurrence rates and poor prognosis, emphasizing the need for standardized glutathione usage during treatment

T.GoodsonW.BrowneP.PatisaulH

Nature 584 , 279285 (2020)

The Nrf2 protein then translocates into the cell nucleus, where it binds to the Antioxidant Response Element (ARE) on the DNA

These findings appear to be a result of disease and not other variables such as age or biological sex, as no significant difference in biological sex distribution within the cohort was found (Students t Test, p = 0.98) (Supplementary Data 1)