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doi: 10.14348/molcells.2023.0028 120 TakagiY.NakamuraT.NishiyamaA.NozakiK.TanakaT.HashimotoN.et al

10.5005/jp-journals-10024-1825

In the pioneering work by Oberley and Buettner published more than four decades ago, these authors suggested for the first time the importance of suppressed SOD2 (Mn-SOD) expression in cancer (Oberley and Buettner 1979)

The above calculation is obviously simplistic as the rates of the two reactions will vary as a function of changes in substrate concentrations following the onset of stress, and kinetic modeling would be required to examine the question more closely

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