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This study had several limitations

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This preparation is designed solely for parenteral use only after addition of solutions that require dilution or must be dissolved in an aqueous vehicle prior

D-CAN is composed of two essential parts: an ASC-binding domain (peptide CSWKYWFGEC) and a pro-apoptotic fragment ( 2.2 Repolarizing tumor-associated macrophages with peptides Tumor-associated macrophages (TAMs) play a central role within the TME, and their reprogramming is intricately linked to the transformation of this environment (Xiang et al., 2021)

Estimation-based protocols drift by 1020% over multi-week timelines, turning what should be controlled research into uncontrolled dosing experiments