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Rigorous human studies are required to determine safety parameters, mechanistic specificity, and potential translational relevance before any clinical applications can be considered

However, for older people or those lacking in intrinsic factor, higher dosages are often prescribed to ensure passive diffusion in the gut

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Additionally, results of experiments performed on normal volunteers in whom intraepidermal nerve fibers were denervated by the application of capsaicin show that cutaneous autonomic nerve fibers regenerate much faster than sensory nerve fibers (28)