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Human Flavin-Containing Monooxygenases

Michikawa M, Fan QW, Isobe I, Yanagisawa K

Cholesteryl esters accumulate in macrophages and cause their transformation into foam cells, which participate in the formation of atherosclerotic plaque (Figure 18.22)

Embryonic development Lactate is significantly increased and indispensable for embryonic development

TMAO-induced inflammation and endothelial dysfunction in human umbilical vein endothelial cells (HUVECs) can be reversed by treatment with the ROS inhibitor N-acetylcysteine (NAC) or by siRNA-mediated knockdown of NLRP3, suggesting that TMAO exerts its pro-inflammatory effects via the ROS/NLRP3 inflammasome [146]