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Though pentavalent organic As toxicity is not as substantial as As(III) and As(V), trivalent organic As has been found to have higher toxicity than their pentavalent counterparts [93], and thus the presence of MMAA(III) and DMAA(III) in soils and sediments has recently drawn attention [94]

Their involvement in cancer cell growth and differentiation, and in the development of resistance to anticancer agents, has made them attractive drug targets

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We thank the whole PTPSP team at EPFL, especially F

Phytochemical studies were also reviewed to identify active compounds and their mechanisms of action