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Even then, the body has regulatory mechanisms to prevent accumulation

[DOI] [PubMed] [Google Scholar] 40.Ikawa M., Okazawa H., Tsujikawa T., Matsunaga A., Yamamura O., Mori T., Hamano T., Kiyono Y., Nakamoto Y., Yoneda M

Giovinale M, Fonnesu C, Soriano A, et al

ICE was originally isolated from mammalian cells as an enzyme essential for the proper processing and biological activation of pro-IL-1, a cytokine involved in mediating cellular inflammatory processes [36, 40, 4246]

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