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After 5 min, 2 mL of 10% AlCl was added, followed by another 5 min of incubation

The majority of IgG1 antibody effector functions are mediated by the Fc domain

Therefore, whether the p21GPX4 axis is a universally present protective mechanism in OA still awaits broader data support (Figure 1)

Sequence alignment analysis of SRD5As across different species, including the plant homolog DET2 involved in the synthesis of phytohormones 41 , indicated that while the residues involved in the binding of NADP are highly conserved, the residues in the DHF-binding pocket are much less conserved (Extended Data Fig