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The molecular mechanisms of SNRIs can be summarized as follows: First, SNRIs inhibit the norepinephrine transporter (NET), which prevents the reuptake of NE into presynaptic neurons, leading to an increased concentration of NE in the synaptic cleft

It may also explain constipation or bloating in some users

What dose of Trazodone is effective for MDD treatment

Notes on GI symptoms by dose phase

Similarly, with the growing emergence of Long COVID cases, many Long COVID symptoms are coinciding with those present in ME/CFS (29)
