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The MTHFR gene variation may also be associated with lower levels of methionine, one of the amino acids needed for the bodys own synthesis of carnitine

Retrieved July 23, 2021, from JY, H., WJ, K., JS, V., MS, F., GA, T., C, D.-L., M, C., K, H., & CM, M

This can create a carnitine deficit as your body cannot make enough to keep up with the supply and demand

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Early research suggested that loading creatine at a total of 25 grams per day (split into five servings) for a week followed by reducing the dosage to five grams a day thereafter was the most effective protocol