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The significance of differences in protein abundance was determined with a Paired T-test for sibling cohort comparisons and a T-test for comparisons of unrelated groups such as Stage 1 versus Stage 3

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In the absence of Smad3, myostatin induces ROS production through the activation of p38 and ERK mitogen-activated protein kinase (MAPK) pathways mediated via TNF- , IL-6, NOX and XO [35]

The spectrum of genetic mutations among patients with hereditary breast and ovarian cancer

Since nucleotide supply plays a critical role in DNA replication, we further performed DNA fiber assay by measuring the lengths of chase IdU-labeled DNA replication tracks that link to pulse CldU-labeling, which is a gold standard for assessing replication stress 32