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One analysis did report a reduced risk of melanoma, but this was a cancer-specific finding rather than evidence that high-dose B vitamins prevent cancer generally

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Our findings firstly demonstrated that MMA accumulation but not serum or dietary B12 was associated with increased cardiovascular mortality risk among patients with CHD

Painful sores inside the mouth Cracked, red skin at the corners of the lips Pale or Yellowish Skin Tone A B12 deficiency may impair red blood cell production, leading to: A washed-out or pale appearance Sometimes a mild yellowing of the skin due to megaloblastic anemia Other (Non-Skin) Symptoms to Watch For Even if skin issues are your main concern, B12 deficiency rarely happens in isolation

Another key difference is availability