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A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci
Several drugs have been studied, but none have demonstrated significant benefits, indicating a need for larger, well-designed, controlled trials
Compared with that of peripheral vessels, BBB permeability is much less, generally allowing passive diffusion of lipophilic molecules less than 500 Da and few hydrogen-bonded donors and/or acceptors under physiological conditions (42, 43)
