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Additionally, silymarin alters glial responses

One limitation is that, in a variety of cell types, Nox transcript levels at baseline do not necessarily predict stimulus-induced activation of the enzymes, and opposing functions of various enzymes have been detected under different physiological conditions

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This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months

Novel haemodialysis (HD) treatment employing molecular hydrogen (H(2))-enriched dialysis solution improves prognosis of chronic dialysis patients: a prospective observational study