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In contrast, positional polar amine substitutions around the quinolinium core not only improved NNMT inhibition as noted previously,[17] but also enabled favorable passive and active transport across membranes (Tables 1 and 2)

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When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives

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