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10.1097/brs.0000000000003054 139 RussoF.AmbrosioL.PeroglioM.GuoW.WanglerS.GewiessJ.et al (2021)

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IIAEK significantly increased the duodenal and jejunal mRNA levels of Abcg5 (the key transporter for cholesterol excretion 15 ), Abcg8 (the key transporter for cholesterol excretion 15 ) , and Akp3 (mouse IAP 16 ) and significantly decreased the duodenal and jejunal mRNA levels of Hmgcr (the rate-limiting enzyme for cholesterol synthesis 17 ), Npc1l1 (the pivotal transporter for cholesterol absorption 18 ), and Srebf2 (the master regulator of cholesterol metabolism 19 ) in WT mice compared to those in the WT, Control group (Fig

Amino lipids are essential for augmenting cellular absorption, facilitating endosomal escape, and raising the overall acceptance of LNPs

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