l carnitine tmao koeth 2013 nature medicine Frontiers Gut Microbiota-Derived TMAO: A Causal

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An early study identified that gut microbiota-derived methylamines or decreased choline bioavailability perform an appreciable role in the progression of insulin resistance and non-alcoholic fatty liver disease (NAFLD) in high-fat diet-fed mice (Kim et al., 2015), and higher fasting plasma TMAO levels have been observed in patients with T2DM (Shan et al., 2017

Esto ocurre por diferentes mecanismos dentro y fuera de la mitocondria

Larginine est un acide amin semi-essentiel, son apport exogne entrane une augmentation de L-Arginine plasmatique et des produits de son mtabolisme comme loxyde nitrique (NO), L-Glutamine et la cratine