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Collectively, these interconnected factors underline the complexity of PD etiology and provide avenues for therapeutic intervention (Figure 3)

Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort

Many of these symptoms arise from neurodegenerative changes outside the hallmark regions [14, 16, 19, 20]

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In addition, these PAAD authors call for well conducted unbiased RCTs with well defined dosing and criteria, or reviews of the literature that either embrace all the available literature or precisely describe why the results of some manuscripts were disregarded, plus better scrutiny of submitted manuscripts by peer reviewers for journals